B6 Carbidopa Death Rate-Mortality

B6 Carbidopa Death Rate-Mortality

The effects of carbidopa on vitamin B6 in the human body (part 2 of 4)

The peer-reviewed literature has documented the inverse correlation between vitamin B6 intake and mortality under various circumstances (see figures 1 and 2 below). When vitamin B6 concentrations decrease, the average group death rate increases; in all the studies I have reviewed, I find that these traits of vitamin B6 offering a longer life are the most impressive and most believable of all nutrient claims that may increase life expectancy. The following are vitamin B6 studies related to living longer.

The following article documents the correlation between increased vitamin B6 concentrations and lowering the risk of death (mortality).

B6 Carbidopa Mortality Inverse Correlatoin with B6 Part 2
Figure 1: In the elderly, higher intake of vitamin B6 lowered the risk of mortality (i.e. as a group people lived longer).
B6 Carbidopa Mortality Inverse Correlatoin with B6 Part 3
Figure 2: This is the largest Vitamin B6 study I have found. One hundred thirty-four thousand four hundred eighty (134,480) participants were followed for ten years into the future after initial screening.

Carbidopa is known to deplete vitamin B6 concentrations to the point that it is so low that none can be detected on laboratory analysis (see Figure 3). The data documented in the following article was obtained from patients who had taken carbidopa for over three years and were taking no drugs or other substances that might deplete vitamin B6.

B6 Carbidopa Mortality Inverse Correlatoin with B6 Part 4

Figure 3

Carbidopa can deplete vitamin B6. A decreasing vitamin B6 concentration is known to be associated with an increasing death rate. We are not making the claim that carbidopa is causing an increased death rate, we leave that to the reader to conclude (see Figure 4).

B6 Carbidopa Parkinsons Disease Death Rate

Figure 4

Carbidopa’s molecular weight is 244.3.1 Pyridoxal-5′-phosphate molecular weight is 247.140.2 One carbidopa molecule binds with one pyridoxal-5′-phosphate molecule. Administering carbidopa 100 mg has the potential to irreversibly deactivate B6 101.16 mg in the free and B6-dependent enzyme-bound forms. A patient taking carbidopa 100 mg per day while ingesting the 2 mg B6 per day United States Recommended Dietary Allowance (US-RDA) for 5 years will have a potential 181,925 mg B6 deficit.

1 Sinemet prescribing information. Merck website. Available from: https://www.merck.com/product/usa/pi_circulars/s/sinemet/sinemet_pi.pdf. Accessed October 8, 2015.
2 Pubchem, pyridoxal phosphate. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/1051#section=Top Accessed October 11, 2015.