B6 Carbidopa – B6 Function Scope
B6 Carbidopa – B6 Function Scope
The effects of carbidopa on vitamin B6 in the human body (part 4 of 4)
Rightly so, vitamin B6 has been called the most diverse vitamin. It is present in all plant and animal life forms. If depletion of vitamin B6 is great enough any of the following functions of the human body may be compromised.
Figure 1:1,2 This is another list of human body functions which require vitamin B6.
Figure 21,2 In reviewing many papers discussing vitamin B6 the exact number of human body functions which require vitamin B6 was a moving number. We found the following information on a National Institute of Health website database.
Figure 3:1,2 L-3,4-dihydroxyphenylalanine (L-dopa) is the most effective and only method for increasing systemic dopamine concentration higher than is possible on the optimally modified diet. Many patients who take L-dopa experience profound nausea, which may prevent them from reaching higher dosing values required for symptom relief. On May 2, 1975, the US Food and Drug Administration (FDA) approved carbidopa (MK-486) a drug whose only indication was the management of L-dopa-induced nausea. Carbidopa is of no benefit in addressing disease symptoms.3,4,5
B6 Carbidopa Function Scope
Efficacy and safety concerns must be addressed before US FDA drug approval. Conceptualize a drug that has no treat¬ment efficacy claims under US FDA guidelines. Its sole indication is the management of the side effect of nausea induced by improperly balanced nutrient administration. It irreversibly binds to and permanently deactivates free PLP and PLP-dependent enzymes while inducing PLP reserve pool depletion. It negatively impacts the function of over 300 enzymes and proteins. Administering vitamin B6 coun¬teracts the carbidopa mechanism of action.3,6,7
Carbidopa prescribing information lacks full disclosure.8 There is no reference to PLP, PLP depletion, irreversible binding to and permanent deactivation of PLP and PLP-dependent molecules, depletion of PLP reserve pools, risks induced by PLP depletion, potential functional compromise of over 300 enzymes, and proteins, or vitamin B6 related nutritional deficiency induction. Simply describing carbidopa and benserazide as decarboxylase inhibitors is analogous to describing a nuclear blast as a window breaker. Chronic administration affects virtually every system in the body.
2 Paiardini A, Contestabile R, Buckle AM, Cellini B. PLP-dependent enzymes. Biomed Res Int. 2014;2014:856076.
3 SINEMET CR (carbidopa and levodopa) tablet, extended release [prescribing information]. Whitehouse Station, NJ: Merck & Co, Inc.; 2014. Available from: https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=69e575b9-f8a5-494f-b736-2520ef505cb0 Accessed July 1, 2014.
4 US Food and Drug Administration [webpage on the Internet]. Drugs@FDA: FDA approved drug products. Silver Spring, MD: US Food and Drug Administration; 2014. Available from: http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm?fuseaction=Search.DrugDetails Accessed July 19, 2014.
5 Airoldi L, Watkins CJ, Wiggins JF, Wurtman RJ. Effect of pyridoxine on the depletion of tissue pyridoxal phosphate by carbidopa. Metabolism. 1978;27(7):771–779.
6 UniProt [webpage on the Internet]. UniProt. UniProt Consortium; 2014. Available from: https://www.uniprot.org/uniprot/?query=pyridoxal+AND+organism%3A%22Homo+sapiens+%5B9606%5D%22&sort=score Accessed July 4, 2014
7 Daidone F, Montioli R, Paiardini A, et al. Identification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors. PLoS One. 2012;7(2):e31610.
8 SINEMET CR (carbidopa and levodopa) tablet, extended release [prescribing information]. Whitehouse Station, NJ: Merck & Co, Inc.; 2014. Available from: http://dailymed.nlm.nih.gov/dailymed/lookup. cfm?setid=69e575b9-f8a5-494f-b736-2520ef505cb0 Accessed July 1, 2014.